Synthetic approach directed at 1-carbapenems and 1-carbapenams.

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Tumor immunotherapy directed at PD-1.

The treatment of cancer by harnessing immune responses has long been pursued. Efforts to turn on the immune system against cancers with inactivated tumor vaccines or intratumor injections of bacterial products to induce local inflammation and recruit an antitumor immune response have led to anecdotal successes. Increasing knowledge about how the immune system is activated, coupled with advances...

متن کامل

Multivalent agents containing 1-substituted 2,3,4-trihydroxyphenyl moieties as novel synthetic polyphenols directed against HIV-1.

The synthesis and the assessment of the anti-HIV activity of a set of molecules inspired by the multivalent structures of some naturally-occurring polyphenols (tannins) are reported. Different multibranched scaffolds have been derived from pentaerythritol as the central core which distribute spatially synthetic polyphenolic subunits based on 1-substituted 2,3,4-trihydroxyphenyl moieties. A tetr...

متن کامل

Synergistic Antipseudomonal Effects of Synthetic Peptide AMP38 and Carbapenems.

The aim was to explore the antimicrobial activity of a synthetic peptide (AMP38) and its synergy with imipenem against imipenem-resistant Pseudomonas aeruginosa. The main mechanism of imipenem resistance is the loss or alteration of protein OprD. Time-kill and minimal biofilm eradication concentration (MBEC) determinations were carried out by using clinical imipenem-resistant strains. AMP38 was...

متن کامل

1 Directed Hypergraphs and Applications ( * )

We deal with directed hypergraphs as a tool to model and solve some classes of problems arising in Operations Research and in Computer Science. Concepts such as connectivity, paths and cuts are defined. An extension of the main duality results to a special class of hypergraphs is presented. Algorithms to perform visits of hypergraphs and to find optimal paths are studied in detail. Some applica...

متن کامل

New Delhi metallo 1: have carbapenems met their doom?

Lise E. Nigrovic, Richard Malley, Dewesh Agrawal, and Nathan Kuppermann, for the Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics Divisions of Emergency Medicine and Infectious Diseases, Children’s Hospital Boston and Harvard Medical School, Boston, Massachusetts; Division of Emergency Medicine, Children’s National Medical Center and George Was...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Chemical and Pharmaceutical Bulletin

سال: 1980

ISSN: 0009-2363,1347-5223

DOI: 10.1248/cpb.28.3494